48975

Gliotoxin aus Gliocladium fimbriatum

≥98.0% (TLC)

• Empirische Formel (Hill-System): C₁₃H₁₄N₂O₄S₂
• CAS-Nummer: 67-99-2
• Molekulargewicht: 326.39
• UNSPSC Code: 12352200
• Beilstein/REAXYS Number: 50675
• MDL number: MFCD00058534

Eigenschaften

• assay: ≥98.0% (TLC)
• solubility: chloroform: 10 mg/mL, clear, colorless
• antibiotic activity spectrum: viruses
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
• InChI: 1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
• InChI key: FIVPIPIDMRVLAY-RBJBARPLSA-N

Beschreibung

General description

Chemical structure: epipolythiodioxopiperazine

Application

Nicht-kompetitiver Hemmer der chymotrypsin-ähnlichen Aktivität des 20S Proteasoms in vitro.

Other Notes

Antiphagocytic and immunomodulating agent which acts by blocking membrane thiol groups

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges