85256

Tamoxifen

analytical standard

• Synonym(e): (Z)-1-(p-Dimethylaminethoxyphenyl)-1,2-diphenyl-1-buten, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamin
• Lineare Formel: C₆H₅C(C₂H₅)=C(C₆H₅)C₆H₄OCH₂CH₂N(CH₃)₂
• CAS-Nummer: 10540-29-1
• Molekulargewicht: 371.51
• NACRES: NA.24
• PubChem Substance ID: 329769367
• UNSPSC Code: 41116107
• EC Number: 234-118-0
• MDL number: MFCD00010454
• eCl@ss: 25140904

Eigenschaften

• grade: analytical standard
• Quality Segment: 100
• assay: ≥98.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable
• impurities: ≤0.7% water
• mp: 97-98 °C (lit.)
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3
• InChI: 1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
• InChI key: NKANXQFJJICGDU-QPLCGJKRSA-N
• Gene Information: human ... ESR1(2099)

Beschreibung

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Proteinkinase C-Inhibitor. Induziert Apoptose in menschlichen malignen Gliomzelllinien. Tamoxifen und sein Metabolit 4-Hydroxytamoxifen sind selektive Östrogenrezeptormodulatoren (SERM), die als Östrogen-Antagonisten in Brustdrüsen wirken. Hemmt die Estradiol-stimulierte VEGF-Produktion in Brustkrebszellen.

Östrogen-Antagonist in der Brustdrüse. Hemmt die Östradiol-stimulierte VEGF-Produktion in Brustkrebszellen. Proteinkinase C-Inhibitor.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Danger
• Gefahrencodes: H350,H360,H410
• Sicherheitshinweise: P201 - P273 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable