229075

1,8-Dihydroxy-3-methylanthrachinon

98%

• Synonym(e): 3-Methylchrysazin, Chrysophansäure
• Empirische Formel (Hill-System): C₁₅H₁₀O₄
• CAS-Nummer: 481-74-3
• Molekulargewicht: 254.24
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 57648009
• EC Number: 207-572-2
• Beilstein/REAXYS Number: 1252300
• MDL number: MFCD00001208

Eigenschaften

• Quality Segment: 100
• assay: 98%
• form: crystalline
• color: yellow-orange
• solubility: chloroform: 1%
• antibiotic activity spectrum: neoplastics, viruses
• mode of action: enzyme | inhibits
• SMILES string: Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
• InChI key: LQGUBLBATBMXHT-UHFFFAOYSA-N
• Gene Information: human ... ELA2(1991)

Beschreibung

Application

Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells . It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro .

Biochem/physiol Actions

Anticancer activity for chrysophanic acid is via the EGFR/mTOR mediated signaling transduction pathway . Chrysophanic acid has two hydrophobic positions on the molecule (C-6 and the methyl group attached to C-3) which are responsible for the compound′s activity against poliovirus .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves