Product H5534 is tested and recommended for cell culture applications. Product 56250 has not been tested for the suitability of cell culture and would need to be validated by the end-user.
Fortfahren mit
56250
Trans-4-Hydroxy-L-Prolin
≥99.0% (NT), BioXtra
Synonym(e):
(2S,4R)-4-Hydroxy-pyrrolidin-2-carbonsäure, Hyp
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Über diesen Artikel
Empirische Formel (Hill-System):
C5H9NO3
CAS-Nummer:
Molekulargewicht:
131.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-091-9
MDL number:
Beilstein/REAXYS Number:
81441
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Technischer Dienst
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Unterstützung erhaltenProduktname
Trans-4-Hydroxy-L-Prolin, BioXtra, ≥99.0% (NT)
product line
BioXtra
Quality Segment
assay
≥99.0% (NT)
form
solid
optical activity
[α]20/D −76.0±1.5°, c = 5% in H2O
impurities
≤0.3% foreign amino acids
ign. residue
≤0.1% (as SO4)
loss
≤0.1% loss on drying, 110 °C
color
colorless to white
mp
273 °C (dec.) (lit.)
anion traces
chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg
cation traces
Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, NH4+: ≤100 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
application(s)
peptide synthesis
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.
Other Notes
Enzymes and intermediates of hydroxyproline degradation
natürliche Komponente von tierischen Proteinen wie Collagen und Elastin
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Dieser Artikel | |||
|---|---|---|---|
| description BioXtra, ≥99.0% (NT) | description analytical standard | description Pharmaceutical Secondary Standard; Certified Reference Material | description BioReagent, suitable for cell culture, ≥98.5% |
| form solid | form - | form - | form crystalline |
| assay ≥99.0% (NT) | assay ≥99% (TLC) | assay - | assay ≥98.5% |
| product line BioXtra | product line - | product line - | product line BioReagent |
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 200 |
| color colorless to white | color white | color - | color colorless |
| cation traces Cu: ≤5 mg/kg, Mg: ≤5 mg/kg, Fe: ≤5 mg/kg, Pb: ≤5 mg/kg, Cd: ≤5 mg/kg, Mn: ≤5 mg/kg, Cr: ≤5 mg/kg, K: ≤50 mg/kg, Na: ≤50 mg/kg, Ca: ≤10 mg/kg, Co: ≤5 mg/kg, Ni: ≤5 mg/kg, Zn: ≤5 mg/kg, NH4+: ≤100 mg/kg | cation traces - | cation traces - | cation traces - |
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Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 1
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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we need to use this component for cell culture. Is 56250 suitable (BioXtra, ≥99.0% (NT)) or we need to order the H5534 (BioReagent, suitable for cell culture, ≥98.5%)
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