90182

N_α-Tosyl-L-lysin-chlormethylketon -hydrochlorid

≥99.0% (AT)

• Synonym(e): (3S)-1-Chlor-3-Tosylamid-7-Amino-2-Heptanon -hydrochlorid, (3S)-7-Amino-1-chlor-3-tosylamino-2-heptanon -hydrochlorid, TLCK, Tosyl-L-lysyl-chlormethan -hydrochlorid
• Empirische Formel (Hill-System): C₁₄H₂₁ClN₂O₃S · HCl
• CAS-Nummer: 4272-74-6
• Molekulargewicht: 369.31
• NACRES: NA.77
• PubChem Substance ID: 57653369
• eCl@ss: 32160406
• UNSPSC Code: 12352202
• EC Number: 224-266-4
• MDL number: MFCD00065395
• Beilstein/REAXYS Number: 7106867

Eigenschaften

• biological source: synthetic
• Quality Segment: 100
• assay: ≥99.0% (AT)
• form: powder or crystals
• optical activity: [α]20/D −7.8±0.5°, c = 2% in H₂O
• input: general use sample(s)
• storage temp.: −20°C
• SMILES string: Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
• InChI: 1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
• InChI key: YFCUZWYIPBUQBD-ZOWNYOTGSA-N

Beschreibung

Other Notes

An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin and clostripain . Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves
• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• Gefahrencodes: H302,H315,H317,H318
• Sicherheitshinweise: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1B