A0956

Angelicin

• Synonym(e): 2-Oxo-(2H)-furo[2,3-h]-1-benzopyran, 2H-Furo[2,3-h]-1-benzopyran-2-on, Isopsoralen, NSC 404563
• Empirische Formel (Hill-System): C₁₁H₆O₃
• CAS-Nummer: 523-50-2
• Molekulargewicht: 186.16
• UNSPSC Code: 85151701
• NACRES: NA.25
• PubChem Substance ID: 24890472
• MDL number: MFCD00064930
• Beilstein/REAXYS Number: 153970
• Form: powder

Eigenschaften

• form: powder
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: O=C1Oc2c(C=C1)ccc3occc23
• InChI: 1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
• InChI key: XDROKJSWHURZGO-UHFFFAOYSA-N

Beschreibung

Application

Angelicin, an angular furocoumarin, may be used as a photoactivatable molecule that reacts with DNA and unsaturated fatty acids to form monoadducts. Angelicin may be studied as a potential phototherapeutic and to understand its mechanisms of action and effects on RNA and DNA synthesis.

Biochem/physiol Actions

Angular furocoumarin with diverse photobiological effects. Upon long-wavelength UV irradiation, forms monoadduct with double-stranded DNA and reacts with unsaturated fatty acids. Inhibits DNA and RNA synthesis and cell replication in Ehrlich ascites tumor cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges