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A2024

Apramycin -sulfat (Salz)

Synonym(e):

Nebramycin II

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Größe/SKUVerfügbarkeitPreis
1 g
Warenkorb auf Verfügbarkeit prüfen
€ 68,80
5 g
Warenkorb auf Verfügbarkeit prüfen
€ 238,00

Über diesen Artikel

Empirische Formel (Hill-System):
C21H41N5O11 · xH2SO4
CAS-Nummer:
Molekulargewicht:
539.58 (free base basis)
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51281633
EC Number:
265-890-7
MDL number:

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biological source

Streptomyces tenebrarius

Quality Segment

form

powder

color

white to brown

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI key

WGLYHYWDYPSNPF-RQFIXDHTSA-N

General description

Chemische Struktur: Aminoglykosid

Application

Apramycin wird zur Untersuchung von Antibiotikaresistenz sowie der Hemmung des Translokationsschritts bei der Proteinsynthese in Bakterien und Prokaryoten eingesetzt.

Biochem/physiol Actions

Apramycin hemmt die Proteinsynthese durch das Blockieren der Translokation. Es kann außerdem an die eukaryotische Dekodierungsstelle binden. Bei geringen Konzentrationen hemmt es die Streckung und induziert eine Fehlablesung von mRNA während der Proteinsynthese.

Packaging

1G, 5G

Other Notes

Behälter dicht verschlossen an einem trockenen und gut gelüfteten Ort aufbewahren. An einem trockenen Ort aufbewahren. Lagerklasse (TRGS 510): Nicht brennbare, akut giftige Kat.3 / giftige Schadstoffe, die chronische Wirkungen verursachen.

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Dieser Artikel
T178360615PHR1487
description

-

description

aminoglycoside antibiotic

description

mixture of Kanamycin A (main component) and Kanamycin B and C

description

Pharmaceutical Secondary Standard; Certified Reference Material

antibiotic activity spectrum

Gram-negative bacteria

antibiotic activity spectrum

Gram-negative bacteria

antibiotic activity spectrum

Gram-positive bacteria, mycobacteria, mycoplasma, Gram-negative bacteria

antibiotic activity spectrum

-

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

powder

form

powder or crystals

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

biological source

Streptomyces tenebrarius

biological source

Streptomyces tenebrarius

biological source

-

biological source

-


Piktogramme

Health hazard

Signalwort

Danger

Gefahrencodes

Hazard Classifications

Repr. 1B

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges



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Analysenzertifikate (COA)

Lot/Batch Number

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Questions

1–3 of 3 Questions  
  1. What is the active fraction of Apramycin in Apramycin sulfate salt (A2024-1G)?

    1 answer
    1. The assay specification for this product is ≥450 µg/mg, indicating that 1 mg of dry material contains at least 450 µg of apramycin sulfate salt. The amount of sulfate varies between batches, so an exact value or specification for apramycin cannot be provided. Each batch also contains some water, as noted on the Certificate of Analysis, which must be considered when weighing the product. The total of all other substances is, according to the Certificate of Analysis, ≤15%.

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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