A2027

L-Arginine-7-amido-4-methylcoumarin hydrochloride

cathepsin H substrate

• Synonym(e): Arginine 4-methyl-7-coumarylamide
• Empirische Formel (Hill-System): C₁₆H₂₁N₅O₃
• CAS-Nummer: 69304-16-1
• Molekulargewicht: 331.37
• NACRES: NA.83
• PubChem Substance ID: 24890618
• UNSPSC Code: 12352204
• MDL number: MFCD00058184

Eigenschaften

• Quality Segment: 200
• assay: ≥97% (TLC)
• form: powder
• solubility: acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow
• storage temp.: −20°C
• SMILES string: Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=N)ccc12
• InChI: 1S/C16H21N5O3.ClH/c1-9-7-14(22)24-13-8-10(4-5-11(9)13)21-15(23)12(17)3-2-6-20-16(18)19;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,21,23)(H4,18,19,20);1H/t12-;/m0./s1
• InChI key: PFLMUQNBZRXRHD-YDALLXLXSA-N

Beschreibung

Application

L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a substrate for cathepsin H from rat muscle homogenate and sarcoplasmic extract. It has also been used as a substrate for arginine amino-peptidase from Daphnia homogenates and recombinant aminopeptidase from Toxoplasma gondii.

Biochem/physiol Actions

L-Arginine-7-amido-4-methylcoumarin hydrochloride is a protease substrate. It is a specific substrate for cathepsin H and not for cathepsin L and B.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)