A4978

Alendronat Natriumsalz Trihydrat

≥97% (NMR), bone resorption inhibitor, powder

• Synonym(e): 4-Amino-1-hydroxy-1-phosphonobutylphosphonsäure, Mononatriumsalz, MK-217
• Empirische Formel (Hill-System): C₄H₁₂NaNO₇P₂ · 3 H₂O
• CAS-Nummer: 121268-17-5
• Molekulargewicht: 325.12
• UNSPSC Code: 41106300
• PubChem Substance ID: 24724391
• NACRES: NA.77
• MDL number: MFCD01748233
• Assay: ≥97% (NMR)
• Form: powder

Eigenschaften

• Produktname: Alendronat Natriumsalz Trihydrat, ≥97% (NMR), powder
• Quality Segment: 100
• assay: ≥97% (NMR)
• form: powder
• color: white
• solubility: water, double-distilled: 10 mg/mL
• storage temp.: −20°C
• SMILES string: [Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
• InChI key: DCSBSVSZJRSITC-UHFFFAOYSA-M
• Gene Information: human ... FDPS(2224)

Beschreibung

Application

Alendronate sodium trihydrate has been used:

• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
• in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
• to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

Biochem/physiol Actions

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.

Natriumalendronat Trihydrat ist ein Knochenresorptionshemmer; Farnesyldiphosphatsynthase Inhibitor (IC₅₀ = 460 nM); CD45 Protein-Tyrosin-Phosphataseinhibitor.

Preparation Note

Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves