A7479

5-AIQ hydrochloride

≥97% (HPLC), solid

• Synonym(e): 5-Aminoisoquinolinone hydrochloride
• Empirische Formel (Hill-System): C₉H₉ClN₂O
• CAS-Nummer: 93117-07-8
• Molekulargewicht: 196.63
• NACRES: NA.77
• PubChem Substance ID: 24724396
• UNSPSC Code: 12352202
• MDL number: MFCD03452659
• Assay: ≥97% (HPLC)
• Form: solid

Eigenschaften

• assay: ≥97% (HPLC)
• form: solid
• color: tan
• solubility: DMSO: >20 mg/mL, H₂O: >20 mg/mL
• storage temp.: −20°C
• SMILES string: Cl[H].Nc1cccc2C(=O)NC=Cc12
• InChI: 1S/C9H8N2O.ClH/c10-8-3-1-2-7-6(8)4-5-11-9(7)12;/h1-5H,10H2,(H,11,12);1H
• InChI key: KWNLARCFSYAXLT-UHFFFAOYSA-N

Beschreibung

Application

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1). 5-AIQ hydrochloride was used in a study that determined PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers and certain retinopathies.

Biochem/physiol Actions

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1).

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves