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A9202

Angiotensin Fragment 1-7 acetate salt hydrate

≥90% (HPLC), powder, RAS heptapeptide

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Größe/SKUVerfügbarkeitPreis
1 mg
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€ 49,40
5 mg
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€ 155,00

Über diesen Artikel

Empirische Formel (Hill-System):
C41H62N12O11 · xC2H4O2 · yH2O
Molekulargewicht:
899.00 (anhydrous free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
powder

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Produktname

Angiotensin Fragment 1-7 acetate salt hydrate, ≥90% (HPLC), powder

Quality Segment

assay

≥90% (HPLC)

form

powder

UniProt accession no.

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O

InChI

1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)

InChI key

PVHLMTREZMEJCG-UHFFFAOYSA-N

Gene Information

human ... AGT(183)

Application

Angiotensin Fragment 1-7 acetate salt hydrate has been used:
  • to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion
  • to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats
  • to study its association with influenza A virus (IAV) infection

Biochem/physiol Actions

Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS). It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR). It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.

Other Notes

Lyophilized from 0.5% acetic acid

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Dieser Artikel
A9650A952510385
description

≥90% (HPLC), powder

description

≥90% (HPLC), powder, suitable for mammalian cell culture

description

≥93% (HPLC), powder

description

≥98% (HPCE)

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥93% (HPLC)

assay

≥98% (HPCE)

form

powder

form

powder

form

powder

form

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01019

UniProt accession no.

P01019

UniProt accession no.

P01019

UniProt accession no.

-

Gene Information

human ... AGT(183)

Gene Information

human ... AGT(183)

Gene Information

human ... AGT(183)

Gene Information

-


Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

Eyeshields, Gloves, type N95 (US)



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Questions

  1. For how long can Angiotensin 1-7 (A9202) be stored at -20?

    1 answer
    1. This product is not assigned an expiration date. It contains a recommended retest date of approximately 5 years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

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