B5399

(±)-Baclofen

≥98% (HPLC), GABAB receptor agonist, solid

• Synonym(e): (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• Empirische Formel (Hill-System): C₁₀H₁₂ClNO₂
• CAS-Nummer: 1134-47-0
• Molekulargewicht: 213.66
• NACRES: NA.32
• PubChem Substance ID: 24278146
• UNSPSC Code: 12352200
• EC Number: 214-486-9
• MDL number: MFCD00055143
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: (±)-Baclofen, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to very faintly yellow
• solubility: 1 M HCl: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• InChI key: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• Gene Information: human ... GABBR1(2550), GABBR2(9568) ; rat ... Gabbr1(81657), Gabra2(29706)

Beschreibung

Application

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

Biochem/physiol Actions

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges