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B5399

(±)-Baclofen

Name: (±)-Baclofen
Brand: SIGMA

≥98% (HPLC), GABAB receptor agonist, solid

Synonym(e):

(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₀H₁₂ClNO₂

CAS-Nummer:

1134-47-0

Molekulargewicht:

213.66

NACRES:

NA.32

PubChem Substance ID:

24278146

UNSPSC Code:

12352200

EC Number:

214-486-9

MDL number:

MFCD00055143

Assay:

≥98% (HPLC)

Form:

solid

Technischer Dienst

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Eigenschaften

Produktname

(±)-Baclofen, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to very faintly yellow

solubility

1 M HCl: 50 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=CC=C(C(CN)CC(O)=O)C=C1

InChI

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

InChI key

KPYSYYIEGFHWSV-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Beschreibung

Application

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
to test its effects on in vivo motor function tests and performance of mutant mice
to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
to test its effect in reducing dendritic excitability in Purkinje neurons

Biochem/physiol Actions

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.