B8686

(+)-N-3-Benzyl Nirvanol

≥98% (HPLC), powder, CYP2C19 inhibitor

• Synonym(e): 5-ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione, 5-ethyl-5-phenyl-3-(phenylmethyl)-hydantoin
• Empirische Formel (Hill-System): C₁₈H₁₈N₂O₂
• CAS-Nummer: 790676-40-3
• Molekulargewicht: 294.35
• UNSPSC Code: 12161501
• PubChem Substance ID: 329773138
• NACRES: NA.77
• MDL number: MFCD09840024
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: (+)-N-3-Benzyl Nirvanol, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >20 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CC[C@]1(NC(=O)N(Cc2ccccc2)C1=O)c3ccccc3
• InChI: 1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)/t18-/m0/s1
• InChI key: ZMZDHUHMXXALFX-SFHVURJKSA-N

Beschreibung

Application

(+)-N-3-Benzylnirvanol may be used as a cytochrome P450 2C19 (CYP2C19) inhibitor in a comparison study to treat cocktail and individual substrates for the screening for potent cytochrome P450 (CYP) inhibition. It may also be used in comparative studies to investigate its potential as CYP and non-CYP selective inhibitors of CYP2C19 in suspended human hepatocytes.

Biochem/physiol Actions

(+)-N-3-Benzylnirvanol serves as an inhibitor of cytochrome P450 2B6 (CYP2B6).

(+)-N-3-Benzyl-nirvanol is a potent selective CYP2C19 inhibitor.

(+)-N-3-Benzyl-nirvanol is a potent selective CYP2C19 inhibitor. CYP2C19 has a high frequency of drug resistance; highly polymorphic.

Sicherheitshinweise

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H319,H400
• pcodes: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves