B9636

S-Benzoylthiamine O-monophosphate

• Synonym(e): Benfotiamine
• Empirische Formel (Hill-System): C₁₉H₂₃N₄O₆PS
• CAS-Nummer: 22457-89-2
• Molekulargewicht: 466.45
• NACRES: NA.79
• PubChem Substance ID: 24892147
• UNSPSC Code: 12352116
• EC Number: 245-013-4
• MDL number: MFCD00057343

Eigenschaften

• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder or crystals
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: Cc1ncc(CN(C=O)\C(C)=C(/CCOP(O)(O)=O)SC(=O)c2ccccc2)c(N)n1
• InChI: 1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+
• InChI key: BTNNPSLJPBRMLZ-GHRIWEEISA-N

Beschreibung

General description

S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.

Application

S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.

Biochem/physiol Actions

S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)