C1493

Cilnidipine

≥98% (HPLC), powder

• Synonym(e): 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester, FRC 8653
• Empirische Formel (Hill-System): C₂₇H₂₈N₂O₇
• CAS-Nummer: 132203-70-4
• Molekulargewicht: 492.52
• NACRES: NA.77
• PubChem Substance ID: 24892414
• UNSPSC Code: 12352200
• MDL number: MFCD00865853
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: light yellow
• solubility: H₂O: ≤2 mg/mL, DMSO: ≥20 mg/mL
• SMILES string: COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC\C=C\c3ccccc3
• InChI: 1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
• InChI key: KJEBULYHNRNJTE-DHZHZOJOSA-N

Beschreibung

Application

Cilnidipine has been used:

• in cell viability assay of pheochromocytoma (nPC12) cells
• in photoirradiation and photodegradation studies
• to understand effect on albuminuria in diabetic nephropathy

Biochem/physiol Actions

A slow-acting Ca²⁺ channel blocker, antihypertensive; vasodilator.

Cilnidipine is a slow-acting Ca²⁺ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca²⁺ channels in vascular smooth muscle and N-type Ca²⁺ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Protect from high temperatures.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• Gefahrencodes: H318
• Sicherheitshinweise: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves