Corticotropin Releasing Factor Antagonist

Name: Corticotropin Releasing Factor Antagonist
Brand: SIGMA

≥97% (HPLC)

Synonym(e):

α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₆₆H₂₇₄N₄₆O₅₃S₂

CAS-Nummer:

99658-03-4

Molekulargewicht:

3826.36

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD00081543

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Eigenschaften

Quality Segment

200

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

Gene Information

human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)

Beschreibung

Biochem/physiol Actions

Exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Dieser Artikel	C2671	C3042	A4933
Sigma-Aldrich C2917 Corticotropin Releasing Factor Antagonist	Sigma-Aldrich C2671 Corticotropin Releasing Factor bovine	Sigma-Aldrich C3042 Corticotropin-freisetzender Faktor, Mensch, Ratte	Sigma-Aldrich A4933 Astressin
description ≥97% (HPLC)	description ≥90% (HPLC), Synthetic	description ≥95% (HPLC), powder	description ≥90% (HPLC)
assay ≥97% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay ≥90% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Gene Information human ... CRH(1392) mouse ... CRH(12918) rat ... CRH(81648)	Gene Information cow ... CRH(280755)	Gene Information human ... CRH(1392)	Gene Information human ... CRH(1392) mouse ... CRH(12918) rat ... CRH(81648)