This product is not tested for biological activity.
Fortfahren mit
C3042
Corticotropin-freisetzender Faktor, Mensch, Ratte
≥95% (HPLC), powder
Synonym(e):
CRF
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
0.1 mg | Warenkorb auf Verfügbarkeit prüfen | € 197,00 |
250 μg | Warenkorb auf Verfügbarkeit prüfen | € 441,00 |
0.5 mg | Warenkorb auf Verfügbarkeit prüfen | € 675,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C208H344N60O63S2
CAS-Nummer:
Molekulargewicht:
4757.45
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Segment
biological source
human, rat
assay
≥95% (HPLC)
form
powder
mol wt
4757.45
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1.00-1.04 mg/mL, colorless
UniProt accession no.
storage temp.
−20°C
InChI key
VXFVFWFSJFSXHN-FAUHKOHMSA-N
Gene Information
human ... CRH(1392)
General description
The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.
Research area: Neuroscience
Research area: Neuroscience
Application
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus
Biochem/physiol Actions
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥95% (HPLC), powder | description ≥97% (HPLC) | description ≥90% (HPLC), Synthetic | description ≥95% (HPLC) |
| biological source human, rat | biological source - | biological source - | biological source - |
| technique(s) activity assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥90% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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What is the effectiveness of this drug
1 answer-
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What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture. The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.
Helpful?
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What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.
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What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide. The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).
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