C4024

Carbamazepin

≥98% (HPLC), powder, sodium channel inhibitor

• Synonym(e): 5H-Dibenz[b,f]azepin-5-carboxamid
• Empirische Formel (Hill-System): C₁₅H₁₂N₂O
• CAS-Nummer: 298-46-4
• Molekulargewicht: 236.27
• UNSPSC Code: 12352200
• eCl@ss: 34051404
• PubChem Substance ID: 57654002
• NACRES: NA.77
• EC Number: 206-062-7
• MDL number: MFCD00005073

Eigenschaften

• Produktname: Carbamazepin, powder
• SMILES string: NC(=O)N1c2ccccc2C=Cc3ccccc13
• InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
• InChI key: FFGPTBGBLSHEPO-UHFFFAOYSA-N
• form: powder
• mp: 191-192 °C (lit.)
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL; H₂O: insoluble; ethanol: soluble; propylene glycol: soluble
• originator: Novartis
• storage temp.: 2-8°C
• Quality Level: 100
• Gene Information: human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Beschreibung

Biochem/physiol Actions

Antikonvulsivum; Ligand für die Benzodiazepin modulatorische Stelle am GABA_A-Rezeptor; Natriumkanalinhibitor.

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.[1]

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration.[2] It has also been used to find out its effects on spontaneous seizures in rats.[3]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334,H336,H360FD
• pcodes: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3
• target_organs: Central nervous system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves