This product has not been tested for the presence of endotoxins. Currently, an endotoxin tested product option is not available.
Fortfahren mit
C4369
Calcipotriol hydrate
≥98% (HPLC), powder, Vitamin D3 analog
Synonym(e):
(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol, Calcipotriene
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
10 mg | Warenkorb auf Verfügbarkeit prüfen | € 230,00 |
50 mg | Warenkorb auf Verfügbarkeit prüfen | € 876,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C27H40O3 · xH2O
CAS-Nummer:
Molekulargewicht:
412.60 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Calcipotriol hydrate, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 15 mg/mL, clear
storage temp.
room temp
SMILES string
O.C[C@H](\C=C\[C@@H](O)C1CC1)C2CCC3\C(CCC[C@]23C)=C\C=C4\C[C@@H](O)C[C@H](O)C4=C
InChI
1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
InChI key
XBKHACNRWFKJNC-MANNPBRJSA-N
Biochem/physiol Actions
Calcipotriol is a synthetic derivative of calcitriol, or Vitamin D.
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description European Pharmacopoeia (EP) Reference Standard | description ≥98% (HPLC) | description United States Pharmacopeia (USP) Reference Standard |
| form powder | form - | form powder | form - |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 15 mg/mL, clear | solubility - | solubility DMSO: 2 mg/mL, clear | solubility - |
Signalwort
Danger
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1B - STOT RE 1
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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