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C4520

Cephalothin Natriumsalz

Name: Cephalothin Natriumsalz
Brand: SIGMA

Synonym(e):

7-(2-Thienylacetamino)-cephalosporansäure Natriumsalz, Cephalotin Natriumsalz

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₆H₁₅N₂NaO₆S₂

CAS-Nummer:

58-71-9

Molekulargewicht:

418.42

UNSPSC Code:

51282506

NACRES:

NA.85

PubChem Substance ID:

24278314

EC Number:

200-394-6

Beilstein/REAXYS Number:

4120706

MDL number:

MFCD00072025

Technischer Dienst

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Unterstützung erhalten

Eigenschaften

form

crystalline powder

Quality Segment

200

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O

InChI

1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1

InChI key

VUFGUVLLDPOSBC-XRZFDKQNSA-M

Beschreibung

General description

Chemical structure: β-lactam

Application

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.