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Merck

C5259

Carbamyl-β-Methylcholinchlorid

≥99% (TLC), crystalline

Synonym(e):

Bethanechol chloride

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Über diesen Artikel

Lineare Formel:
C7H17N2O2Cl
CAS-Nummer:
Molekulargewicht:
196.68
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
209-686-8
MDL number:
Assay:
≥99% (TLC)
Form:
crystalline
Quality level:

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Produktname

Carbamyl-β-Methylcholinchlorid, ≥99% (TLC), crystalline

InChI key

AIRHOJQHGLTTTB-UHFFFAOYSA-N

InChI

1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H

SMILES string

Cl.CC(C[N](C)(C)C)OC(N)=O

assay

≥99% (TLC)

form

crystalline

color

white

solubility

H2O: 1.7 g/mL (stable for several days at 4°C.)
ethanol: 80 mg/mL (stable for several days at 4°C.)

storage temp.

2-8°C

Quality Level

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Dieser Artikel
T4376A0779B107
assay

≥99% (TLC)

assay

≥97% (TLC)

assay

-

assay

≥97% (NMR)

form

crystalline

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: 1.7 g/mL (stable for several days at 4°C.), ethanol: 80 mg/mL (stable for several days at 4°C.)

solubility

DMSO: >10 mg/mL (stable for several months at 4°C.), ethanol: 20 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C)

solubility

H2O: soluble (solutions may be stored for several days at 4 °C)

color

white

color

white

color

white

color

white to beige

Application

Carbamyl-β-methylcholine chloride has been used in western blotting and bactericidal assay.[1] It has also been used in concentration-response studies with isolated atrial preparation.[2]

Biochem/physiol Actions

Carbamyl-β-methylcholine has a selective action on urinary bladder and intestine.[3] It induces smooth muscle tension in the bladder.[4] Its main function is to induce detrusor muscle action, mediated by postganglionic parasympathetic effector cells.[5] Nausea, flushing, sweating, abdominal cramps are some of the side effect caused by carbamyl-β-methylcholine.[6]

Disclaimer

Hygroscopic.

General description

Muscarinic acetylcholine receptor agonist that is not a substrate for acetylcholinesterase.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Die Dokumentenbibliothek aufrufen

Jagmohan Singh et al.
Gastroenterology, 143(5), 1308-1318 (2012-08-07)
Patients with systemic sclerosis (SSc) have impairments in gastrointestinal smooth muscle function. The disorder has been associated with circulating antibodies to cholinergic muscarinic the type-3 receptor (M(3)-R). We investigated whether it is possible to neutralize these antibodies with pooled human
Munenori Nagao et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 16(2), 334-343 (2011-11-08)
Our aim was to determine mechanisms of action of the gasotransmitter hydrogen sulfide (H(2)S) on contractile activity in circular muscle of rat jejunum. Jejunal circular muscle strips were prepared to measure isometric contractions. Effects of sodium hydrosulfide (NaHS), a H(2)S
Adult and Pediatric Urology, 1, 1127-1127 (2002)
Ana Beatriz Albino de Almeida et al.
Journal of medicinal food, 15(4), 378-383 (2011-12-24)
Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from A.
Generation of a human urinary bladder smooth muscle cell line.
Zheng Y, Chang S, Boopathi E, et al.
In Vitro Cellular & Developmental Biology, 48, 84-96 (2012)

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