Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

C6048

Cefmetazole sodium salt

Name: Cefmetazole sodium salt
Brand: SIGMA

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern

Größe/SKU	Verfügbarkeit	Preis

Über diesen Artikel

Lineare Formel:

C₁₅H₁₆N₇O₅S₃Na

CAS-Nummer:

56796-39-5

Molekulargewicht:

493.52

NACRES:

NA.85

PubChem Substance ID:

24278328

UNSPSC Code:

51282205

MDL number:

MFCD00214260

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Eigenschaften

form

powder

Quality Segment

200

shelf life

limited shelf life, expiry date on the label

solubility

H₂O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)CSCC#N)OC)C([O-])=O

InChI

1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1

InChI key

BITQGIOJQWZUPL-PBCQUBLHSA-M

Beschreibung

General description

Chemical structure: β-lactam

Application

Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than PBP2 on bacterial cell wall mucopeptide synthesis. Cefmetazole is used to study protein mediated transport of antibiotics.

Biochem/physiol Actions

Cefmetazole disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cefmetazole mimics the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan. It is effective against both Gram-positive and Gram-negative bacteria.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic Handle and store under inert gas.

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 1

Dieser Artikel	1097782	A3862	C3809
Sigma-Aldrich C6048 Cefmetazole sodium salt	USP 1097782 Cefmetazol	Sigma-Aldrich A3862 Cefpirome sulfate	Sigma-Aldrich C3809 Ceftazidim Hydrat
description -	description United States Pharmacopeia (USP) Reference Standard	description -	description 90.0-105.0%, contains ~10% sodium carbonate as stabilizer
antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria	antibiotic activity spectrum -	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
mode of action cell wall synthesis \| interferes	mode of action -	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes
Quality Level 200	Quality Level -	Quality Level 200	Quality Level 200
form powder	form -	form powder	form powder or crystals
solubility H₂O: 50 mg/mL	solubility -	solubility -	solubility -
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C