C6617

CBIQ

≥98% (HPLC), solid

• Synonym(e): 4-Chlorobenzo[f]isoquinoline
• Empirische Formel (Hill-System): C₁₃H₈NCl
• CAS-Nummer: 32081-28-0
• Molekulargewicht: 213.66
• NACRES: NA.77
• PubChem Substance ID: 24724450
• UNSPSC Code: 12352200
• MDL number: MFCD02179769
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: 15 mg/mL
• SMILES string: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
• InChI key: SHQLTRRYZVBEMR-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K⁺ channel (KCNN4) activator.

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Features and Benefits

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06,GHS05
• Signalwort: Danger
• Gefahrencodes: H301,H315,H318,H335
• Sicherheitshinweise: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges