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D048

MPP⁺ iodide

Name: MPP<SUP>+</SUP> iodide
Brand: SIGMA

≥98% (HPLC), ERα antagonist, powder

Synonym(e):

1-Methyl-4-phenylpyridinium iodide

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₂H₁₂IN

CAS-Nummer:

36913-39-0

Molekulargewicht:

297.13

UNSPSC Code:

12352200

PubChem Substance ID:

24893235

NACRES:

NA.77

MDL number:

MFCD00055096

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Eigenschaften

Produktname

MPP⁺ iodide, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 10 mg/mL, clear

SMILES string

[I-].C[n+]1ccc(cc1)-c2ccccc2

InChI

1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

InChI key

RFDFRDXIIKROAI-UHFFFAOYSA-M

Beschreibung

General description

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Application

MPP+ iodide has been used:

to induce oxidative stress in zebrafish embryos
for the inhibition of glutamate uptake in mitochondria of astrocytes
in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells