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D0676

Dobutamin -hydrochlorid

Name: Dobutamin -hydrochlorid
Brand: SIGMA

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

Synonym(e):

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamin -hydrochlorid

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₈H₂₃NO₃ · HCl

CAS-Nummer:

49745-95-1

Molekulargewicht:

337.84

NACRES:

NA.77

PubChem Substance ID:

24277772

UNSPSC Code:

12352116

EC Number:

256-464-1

MDL number:

MFCD00153795

eCl@ss:

32150312

Assay:

≥98%

Form:

powder

Technischer Dienst

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Eigenschaften

Produktname

Dobutamin -hydrochlorid, ≥98%

Quality Segment

200

assay

≥98%

form

powder

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

Beschreibung

Application

Dobutamine hydrochloride has been used:

to treat mouse embryonic fibroblasts for cell death analysis
to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.