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Merck

D3447

Doxycyclin -hydrochlorid

Synonym(e):

2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-

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500 MG

€ 75,70

€ 75,70


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Über diesen Artikel

Empirische Formel (Hill-System):
C22H24N2O8 · HCl
CAS-Nummer:
Molekulargewicht:
480.90
MDL-Nummer:
UNSPSC-Code:
51284028
NACRES:
NA.85

Fortfahren mit

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Unterstützung erhalten

Biologische Quelle

synthetic

Qualitätsniveau

Form

powder

Farbe

yellow

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites

Wirkungsweise

protein synthesis | interferes

Lagertemp.

−20°C

InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

InChIKey

VLUQVUWDECWBTL-UQVCFKGQSA-N

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Dieser Artikel
D3072D9891PHR1145
mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, mycoplasma, Gram-positive bacteria, parasites

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

antibiotic activity spectrum

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

liquid

form

powder

form

-

biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

Allgemeine Beschreibung

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Anwendung

Doxycycline hydrochloride has been used for the induction of shRNA expression and induction of expression vectors.[1][2][3]

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Piktogramme

Health hazardExclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells
Debra A et al.
Molecular Vision, 22(40) (2016)
C3 transferase gene therapy for continuous conditional RhoA inhibition
Claire-Anne G et al.
Neuroscience, 339 (2016)
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
Beate H et al.
BMC Cancer (2018)
John D Chan et al.
Nature communications, 8(1), 1910-1910 (2017-12-07)
Schistosomiasis is a debilitating tropical disease caused by infection with parasitic blood flukes. Approximately 260 million people are infected worldwide, underscoring the clinical and socioeconomic impact of this chronic infection. Schistosomiasis is treated with the drug praziquantel (PZQ), which has
David van Dijk et al.
Cell, 174(3), 716-729 (2018-07-03)
Single-cell RNA sequencing technologies suffer from many sources of technical noise, including under-sampling of mRNA molecules, often termed "dropout," which can severely obscure important gene-gene relationships. To address this, we developed MAGIC (Markov affinity-based graph imputation of cells), a method that

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. IS DOXYCYCLINE HYDROCHLORIDE (D3447) SOLUBLE IN WATER 50 MG/ML?

    1 answer
    1. This product is soluble in water at 50 mg/ml.

      Helpful?

  4. What is the best way to solubilize the product for cell culture and animal use?

    1 answer
    1. This product has not been tested for use in cell culture. However, product D5207 is a cell culture tested Doxycycline Hyclate. The Hyclate and the Hydrochloride salt forms are soluble in water at roughly equal rates. For dosing purposes, the unique molecular weight of each must be considered. Please see the link below to the product data sheet for the cell culture version of this product. This information offered in this document may be applied to the D3447:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdf

      Note that neither of these products are sterile. Prepared stock solutions must be filter sterilized prior to adding them to the culture medium.

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