Unfortunately, no data for Product D4008's use with flow cytometry application is determined. However, several academic publications associated with this product's use in flow cytometry experiments may provide details that can assist with the experimental design. Please see the link to those publications below:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C26&q=%22Dansylcadaverine%22+%22D4008%22+%22flow+cytometry%22&btnG=
Fortfahren mit
D4008
Dansylcadaverin
≥97% (TLC)
Synonym(e):
N-(5-Aminopentyl)-5-dimethylamino-1-naphthalinsulfonamid
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
250 mg | Warenkorb auf Verfügbarkeit prüfen | € 78,20 |
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 105,00 |
1 g | Warenkorb auf Verfügbarkeit prüfen | € 630,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C17H25N3O2S
CAS-Nummer:
Molekulargewicht:
335.46
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
EC Number:
233-326-9
Beilstein/REAXYS Number:
2951070
MDL number:
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenQuality Segment
assay
≥97% (TLC)
form
powder
storage temp.
−20°C
SMILES string
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
InChI
1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key
MLEBFEHOJICQQS-UHFFFAOYSA-N
General description
Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.
Application
Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:
- as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)
- to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)
- in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)
Biochem/physiol Actions
Der autofluoreszierende Farbstoff Dansylcadaverin, oder Monodansylcadaverin (MDC), wird häufig verwendet, um Autophagie zu überwachen. MDC wird, durch eine Kombination von Ionenfallen und spezifische Wechselwirkungen mit Membranlipiden, bevorzugt in autophagischen Vakuolen anreichert.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
air sensitive, handled under inert gas
Other Notes
Die Löslichkeit von Dansylcadaverin wird in Methanol getestet (10 mg/mL). Es ist bekannt, dass Dansylcadaverin auch in DMSO und Essigsäure löslich ist.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥97% (TLC) | description BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | description analytical standard | description A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). |
| assay ≥97% (TLC) | assay ≥99.0% (HPLC) | assay ≥95.0% (HPLC) | assay ≥98% (HPLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form - | form - | form solid |
Still not finding the right product?
Explore all of our products under Dansylcadaverin
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
-
Can I use Dansylcadaverine D4008 for detection of autophagy using flow cytometry? if Yes which laser should we use to detect the MDC signal? Di you have any recommendations regarding the final concentration of MDC for detection of autophagy in lymphocyte?
1 answer-
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
Can Dansylcadaverine be use as a marker of autophagic vacuoles?
1 answer-
Dansylcadaverine is a lysosomotropic compound that can be used for the identification of autophagic vacuoles. Please refer to the literature for application-specific protocols.
Helpful?
-
-
What is Product D4008, Dansylcadaverine, soluble in?
1 answer-
We test the solubility of this product in acetic acid at a concentration of 50 mg/mL, with the application of heat and sonication. It has also been reported as being soluble in methanol and DMSO. We have not validated this claim in our labs.
Helpful?
-
-
What is the solution stability of Product D4008, Dansylcadaverine?
1 answer-
According to one source a stock solution of monodansylcadaverine was prepared in methanol at 50 mM and stored frozen at -20°C. No time frame for long-term solution stability was given.
Helpful?
-