Wichtige Dokumente

Gesamtdokumentation anzeigen

D4505

5,5-Diphenylhydantoin Natriumsalz

Name: 5,5-Diphenylhydantoin Natriumsalz
Brand: SIGMA

≥99%

Synonym(e):

5,5-Diphenyl-2,4-imidazolidindion, Phenytoin

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern

Über diesen Artikel

Lineare Formel:

C₁₅H₁₁N₂O₂Na

CAS-Nummer:

630-93-3

Molekulargewicht:

274.25

NACRES:

NA.77

PubChem Substance ID:

24277707

UNSPSC Code:

12352200

EC Number:

211-148-2

MDL number:

MFCD00069674

Assay:

≥99%

Form:

powder

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Eigenschaften

Quality Segment

200

assay

≥99%

form

powder

solubility

aqueous base: soluble

SMILES string

[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1

InChI key

FJPYVLNWWICYDW-UHFFFAOYSA-M

Gene Information

human ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

Beschreibung

General description

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

Application

5,5-Diphenylhydantoin sodium salt has been used:

in the cream preparation for treating burn wounds
in seizure behavior testing as an anticonvulsant in Drosophila
in in vivo embryo toxicity test in mouse embryonic stem cells

Biochem/physiol Actions

Verringert die Inzidenz von tonisch-klonischen Krampfanfällen; scheint erregbare Membranen zu stabilisieren.

Verringert die Inzidenz von tonisch-klonischen Krampfanfällen; scheint erregbare Membranen, vermutlich durch Effekte auf Na⁺-, K⁺- und Ca²⁺Kanäle, zu stabilisieren.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.