D4813

Dendrotoxin-K

≥98% (HPLC), potassium channels inhibitor, lyophilized powder

• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01866187
• Assay: ≥98% (HPLC)
• Form: lyophilized powder

Eigenschaften

• Produktname: Dendrotoxin-K, ≥98% (HPLC), lyophilized powder
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: lyophilized powder
• mol wt: 6,542 Da
• storage temp.: −20°C

Beschreibung

Application

Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice.

Biochem/physiol Actions

Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.

Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Purified by a modification of the method of Schweitz.

Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock

Other Notes

Isolated initially from Dendroaspis polylepis polylepis venom

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)