Esterase aus Kaninchenleber

Name: Esterase aus Kaninchenleber
Brand: SIGMA

lyophilized powder, ≥30 units/mg protein

Synonym(e):

Carboxyl esterase

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Über diesen Artikel

CAS-Nummer:

9016-18-6

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-773-7

MDL number:

MFCD00131030

EG-Nummer:

3.1.1.1 (BRENDA, IUBMB)

Specific activity:

≥30 units/mg protein

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Eigenschaften

form

lyophilized powder

Quality Segment

200

specific activity

≥30 units/mg protein

mol wt

60 kDa

composition

Protein, ≥85% biuret

storage temp.

−20°C

Beschreibung

General description

Esterase belongs to the C-family of carboxylesterases. It is a glycoprotein, mainly present in the endoplasmic reticulum of hepatocytes.

Application

The enzyme from Sigma has been used to study the effect of divalent metal ions on the activity of esterase.

Esterase from rabbit liver has been used:

in comparative biophysical studies with bovine bile-salt-activated lipase in the assays with vinyl acetate, triacylglycerols, p-nitrophenyl esters and serine enzyme inhibitors
in the catalysis and kinetic profiling studies of peptidic compounds
in in vitro stability assays of prodrug compounds (BMS-292655 and BMS300043)
in the hydrolysis of oleuropein aglycone (Ole-AG)

Esterase from rabbit liver has been used in a study to investigate a toxic effect of carbamate insecticides. Esterase from rabbit liver has also been used in a study to investigate the effect of simvastatin on expression and activity of a lipoprotein-associated phospholipase A(2).

Biochem/physiol Actions

Esterase enzyme catalyzes hydrolysis of carboxylic ester to carboxylate and alcohol in the presence of water. Rabbit liver carboxylesterase catalyzes enantioselective hydrolysis of cineol derivatives.

Esterase enzyme has broad substrate specificity. Esterase from rabbit liver has been used to investigate the toxic effect of carbamate insecticides. Esterase from rabbit liver has also been used for the hydrolysis of simvastatin.