E7138

Ethosuximid

T-type calcium channel antagonist

• Synonym(e): 2-Ethyl-2-methylsuccinimid
• Empirische Formel (Hill-System): C₇H₁₁NO₂
• CAS-Nummer: 77-67-8
• Molekulargewicht: 141.17
• NACRES: NA.77
• PubChem Substance ID: 24278423
• UNSPSC Code: 12352111
• EC Number: 201-048-7
• MDL number: MFCD00072123

Eigenschaften

• Produktname: Ethosuximid,
• Quality Segment: 100
• solubility: ethanol: 100 mg/mL
• SMILES string: O=C1NC(CC1(C)CC)=O
• InChI: 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
• InChI key: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• Gene Information: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Beschreibung

Application

Ethosuximide has been used:

• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves