Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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E8750
α-Oestradiol
synthetic (organic), ≥98% (TLC), Endogenous estrogen receptor agonist, powder
Synonym(e):
α-Estradiol, 1,3,5(10)-Estratrien-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratrien, Epiestradiol
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 174,00 |
500 mg | Warenkorb auf Verfügbarkeit prüfen | € 394,00 |
1 g | Warenkorb auf Verfügbarkeit prüfen | € 648,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C18H24O2
CAS-Nummer:
Molekulargewicht:
272.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-354-8
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
α-Oestradiol, powder, ≥98% (TLC)
biological source
synthetic (organic)
Quality Segment
assay
≥98% (TLC)
form
powder
color
white to slight yellow
solubility
ethanol: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChI key
VOXZDWNPVJITMN-SFFUCWETSA-N
Gene Information
human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208)
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
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Dieser Artikel | |||
|---|---|---|---|
| description powder, ≥98% (TLC) | description - | description ≥97% | description ≥99% |
| assay ≥98% (TLC) | assay ≥98.00% (TLC) | assay ≥97% | assay ≥99% |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility ethanol: 50 mg/mL, clear, colorless | solubility chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless to faintly yellow | solubility pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow | solubility chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow |
| color white to slight yellow | color - | color - | color - |
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Danger
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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What is the Department of Transportation shipping information for this product?
1 answer-
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How can I dissolve α-Estradiol, Product No. E8750?
1 answer-
This chemical is soluble in ethanol at 50 mg/mL with heating, and in DMSO at 27 mg/mL. Use of freshly prepared solutions is recommended.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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Is Product E8750, α-Estradiol, tested in cell culture?
1 answer-
No specific suitability tests for cell culture applications have been performed by Sigma. The product is not sterile and has not been tested for endotoxins.
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What is the difference between α-Estradiol (Product No. E8750) and β-Estradiol?
1 answer-
α-Estradiol has been reported as being less feminizing than β-Estradiol while still having significant biological properties. See Moos, W.H., et al, "17α-Estradiol:a less-feminizing estrogen", Drug Development Research, 69(4), 177-184 (2008).
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