E9406

Epirubicin -hydrochlorid

≥90% (HPLC)

• Synonym(e): 4′-Epidoxorubicin -hydrochlorid, Epidoxorubicin -hydrochlorid
• Empirische Formel (Hill-System): C₂₇H₂₉NO₁₁ · HCl
• CAS-Nummer: 56390-09-1
• Molekulargewicht: 579.98
• NACRES: NA.85
• PubChem Substance ID: 329799084
• UNSPSC Code: 51102829
• EC Number: 260-145-2
• MDL number: MFCD00941448

Eigenschaften

• biological source: synthetic
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• color: red to deep red
• solubility: H₂O: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: −20°C
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBSZODSSA-N

Beschreibung

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Biochem/physiol Actions

Zellpermeables Anthracyclin. Ein Antitumor-Antibiotikum und Antineoplastikum. Ein Stereoisomer von Doxorubicin, das reduzierte Kardiotoxizität aufweist. Die Antitumor Aktivitäten sind ausgerichtet auf Topoisomerase II.

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• Gefahrencodes: H302,H340,H350,H360
• Sicherheitshinweise: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves