Wichtige Dokumente

Gesamtdokumentation anzeigen

F4381

Furosemid

Name: Furosemid
Brand: SIGMA

≥98% (HPLC), powder, NKCC symporter inhibitor

Synonym(e):

4-Chlor-N-furfuryl-5-sulfamoylanthranilsäure, 5-(Aminosulfonyl)-4-chlor-2-[(2-furanylmethyl)-amino]-benzoesäure

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern

Über diesen Artikel

Empirische Formel (Hill-System):

C₁₂H₁₁ClN₂O₅S

CAS-Nummer:

54-31-9

Molekulargewicht:

330.74

NACRES:

NA.77

PubChem Substance ID:

24277714

UNSPSC Code:

12352200

EC Number:

200-203-6

MDL number:

MFCD00010549

Assay:

≥98% (HPLC)

Form:

powder

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Eigenschaften

Produktname

Furosemid,

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

mp

220 °C (dec.) (lit.)

solubility

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

originator

Sanofi Aventis

storage temp.

room temp

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

human ... ALB(213), CYP1A2(1544), SLC12A1(6557)

Beschreibung

General description

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:

to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

Hemmt den Ionen-Co-Transport in der Niere

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.