F5006

2-Fluor-2-Desoxy-D-Glucose

glycosylation inhibitor, glucose analog

• Synonym(e): 2-Deoxy-2-fluor-D-glucose, FDG
• Empirische Formel (Hill-System): C₆H₁₁FO₅
• CAS-Nummer: 29702-43-0
• Molekulargewicht: 182.15
• NACRES: NA.32
• PubChem Substance ID: 24894876
• UNSPSC Code: 41116107
• MDL number: MFCD00077527

Eigenschaften

• Quality Segment: 300
• assay: ≥98.00% (TLC)
• form: powder
• mol wt: 182.15 g/mol
• concentration: ≤100% (2-Fluoro-2-deoxy-D-glucose)
• technique(s): protein detection: suitable
• color: , white to white with yellow cast
• mp: 174-176 °C
• solubility: water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: OCC1OC(O)C(F)C(O)C1O
• InChI: 1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2
• InChI key: ZCXUVYAZINUVJD-UHFFFAOYSA-N

Beschreibung

General description

2-Fluoro-2-deoxy-D-glucose is non-toxic and a structural analog of glucose, significantly inhibiting glycosylation. As a glucose analog, uptake of 2-Fluoro-2-deoxy-D-glucose is rapid in brain and heart cells.

2-Fluoro-2-deoxy-D-glucose can be taken up by cells but does not undergo metabolic glycolysis.

Application

2-Fluoro-2-deoxy-D-glucose is used as a tracer for rapid tumor detection. It is used as a glucose analog to study glucose uptake in mice with radiation and burn injuries. Oncology therapy studies use FDG in combination with PET (Positron Emission Topography)

Biochem/physiol Actions

Glucose analog that inhibits cellular glycosylation.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves