F6020

Fenofibrat

≥99% (TLC), powder, PPARα agonist

• Synonym(e): 2-[4-(4-Chlorbenzoyl)-phenoxy]-2-methyl-propansäure-isopropylester
• Empirische Formel (Hill-System): C₂₀H₂₁ClO₄
• CAS-Nummer: 49562-28-9
• Molekulargewicht: 360.83
• NACRES: NA.77
• PubChem Substance ID: 24278015
• UNSPSC Code: 12352200
• EC Number: 256-376-3
• MDL number: MFCD00133314
• Assay: ≥99%
• Form: powder

Eigenschaften

• Produktname: Fenofibrat, ≥99%, powder
• Quality Segment: 100
• assay: ≥99%
• form: powder
• color: off-white
• originator: Abbott
• storage temp.: room temp
• SMILES string: CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2
• InChI: 1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
• InChI key: YMTINGFKWWXKFG-UHFFFAOYSA-N
• Gene Information: human ... PPARA(5465)

Beschreibung

Application

Fenofibrate has been used:

• to study its effect on plasma lipids, liver phenotype and gene expression
• to study its impact on endothelium-dependent vasodilatation of thoracic aorta
• to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Biochem/physiol Actions

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H373
• pcodes: P260 - P314 - P501
• Hazard Classifications: STOT RE 2 Oral
• target_organs: Liver
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves