There's only the CoA for F8257. It's soluble at 50 mg/mL in CHCl3:MeOH (1:1) according to the CoA. Please consult the available literature for the use of solvents in in vitro testing.
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F8257
Flunarizin -dihydrochlorid
≥98% (TLC), T-type Ca2+/Na+ channel blocker
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Synonym(e):
1-[Bis-(4-fluorphenyl)-methyl]-4-(3-phenyl-2-propenyl)-piperazin -dihydrochlorid
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 g | Warenkorb auf Verfügbarkeit prüfen | € 95,30 |
10 g | Warenkorb auf Verfügbarkeit prüfen | € 461,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C26H26F2N2 · 2HCl
CAS-Nummer:
Molekulargewicht:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
Assay:
≥98% (TLC)
Technischer Dienst
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Unterstützung erhaltenProduktname
Flunarizin -dihydrochlorid, ≥98% (TLC)
Quality Segment
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels.
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (TLC) | description European Pharmacopoeia (EP) Reference Standard | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (TLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| originator Johnson & Johnson | originator - | originator - | originator - |
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Signalwort
Warning
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 4 Oral
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
dust mask type N95 (US), Eyeshields, Gloves
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For in vitro testing, in what solvent can it be dissolved? DMSO or other. Also, we require product datasheet which is not available on the website
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