H3757

Hyaluronidase aus Rindertestes

Type VIII, lyophilized powder, 300-1,000 U/mg

• Synonym(e): Hyaluronat-4-glycanhydrolase, Hyaluronoglucosaminidase
• CAS-Nummer: 37326-33-3
• UNSPSC Code: 12352204
• NACRES: NA.54
• EC Number: 253-464-3
• MDL number: MFCD00131351
• EG-Nummer: 3.2.1.35 (BRENDA, IUBMB)
• Specific activity: 300-1,000 U/mg
• Biological source: bovine testis

Eigenschaften

• biological source: bovine testis
• Quality Segment: 200
• conjugate: conjugate (Glucosaminoglycan)
• type: Type VIII
• form: lyophilized powder
• specific activity: 300-1,000 U/mg
• mol wt: ~55 kDa (four subunits of 14 kDa each)
• UniProt accession no.: Q5E985, Q8SQG8
• relevant disease(s): cancer
• storage temp.: −20°C
• Gene Information: cow ... HYAL1(515397), HYAL2(281838)

Beschreibung

Biochem/physiol Actions

Diese Enzyme spalten randomisiert β-N-acetylhexosamin-[1→4]-glycosidische Bindungen in Hyaluronsäure, Chondroitin und Chondroitin-Sulfaten.

Hyaluronidase baut Hyaluronan ab und wird während der Krebsprogredienz unangemessen reguliert.

Preparation Note

Prepared from aseptic filled solution of Type I-S.

Other Notes

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).

View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H334
• Sicherheitshinweise: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)