I4909

Ifosfamid

≥98%

• Synonym(e): Ifex, N,3-Bis-(2-chlorethyl)-tetrahydro-2H-1,3,2-oxazaphosphorin-2-amin-2-oxid
• Empirische Formel (Hill-System): C₇H₁₅Cl₂N₂O₂P
• CAS-Nummer: 3778-73-2
• Molekulargewicht: 261.09
• NACRES: NA.25
• PubChem Substance ID: 329815378
• UNSPSC Code: 41116107
• EC Number: 223-237-3
• MDL number: MFCD00057374
• Assay: ≥98%

Eigenschaften

• Quality Segment: 200
• assay: ≥98%
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: ClCCNP1(=O)OCCCN1CCCl
• InChI: 1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
• InChI key: HOMGKSMUEGBAAB-UHFFFAOYSA-N

Beschreibung

Application

• Ewing sarcoma of the pancreas: a pediatric case report and narrative literature review: This study explores the effectiveness of Ifosfamide in the treatment of rare pediatric Ewing sarcoma of the pancreas, providing valuable insights into the chemotherapeutic management of rare cancers (Liu et al., 2024).


• Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience: Highlights the role of Ifosfamide in osteosarcoma treatment as part of a clinical trial, evaluating its impact on survival rates and treatment outcomes (Bastard et al., 2024).


• Case report: Characteristics and nature of primary cardiac synovial sarcoma: Discusses the utilization of Ifosfamide in managing primary cardiac synovial sarcoma, with an emphasis on its pharmacodynamics and therapeutic efficacy (Kawasaki et al., 2024).


• Dedifferentiated liposarcoma of the spermatic cord: Examines Ifosfamide′s mechanism of action in treating dedifferentiated liposarcoma, contributing to the broader understanding of its application in sarcoma therapy (Panther et al., 2024).


• A Rare Case of Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Associated With Hemophagocytic Lymphohistiocytosis in a Patient With Recurrent Sinusitis: This article details the clinical use of Ifosfamide in treating aggressive lymphoma, underscoring its role in complex cases where standard treatments may not suffice (Christensen et al., 2024).

Biochem/physiol Actions

Ifosfamid ist eine Stickstoff-Senfgas-Verbindung und ein strukturelles Isomer von Cyclophosphamid. Ifosfamid ist ein Prodrug und muss durch das Cytochrom P450 zur biologisch aktiven Komponente transformiert werden. Es wird als antineoplastischer Wirkstoff in der Chemotherapie verwendet, doch die Wahrscheinlichkeit einer Nierentoxizität ist bei Ifosamid größer als bei Cyclophosphamid.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• Gefahrencodes: H301,H319,H340,H350,H360FD
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• Sicherheitshinweise: P202 - P264 - P280 - P301 + P310 + P330 - P305 + P351 + P338 - P308 + P313