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K2644
Kisspeptin-234 trifluoroacetate salt
≥95% (HPLC)
Synonym(e):
kisspeptin-10 peptide 234
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 mg | Warenkorb auf Verfügbarkeit prüfen | € 183,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C63H78N18O13 · xC2HF3O2
CAS-Nummer:
Molekulargewicht:
1295.41 (free base basis)
NACRES:
NA.32
UNSPSC Code:
12352200
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥95% (HPLC)
form
film
color
colorless to white
solubility
H2O: >1 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site.
Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.
Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.
Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.
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Dieser Artikel | ||
|---|---|---|
| description ≥95% (HPLC) | description A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). | description clone 8H4.1, from mouse |
| assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form film | form lyophilized solid | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. - |
| color colorless to white | color white | color - |
| solubility H2O: >1 mg/mL | solubility DMSO: 5 mg/mL | solubility - |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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