L9787

L-655,708

≥98% (HPLC), powder

• Synonym(e): Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate, L-655708
• Empirische Formel (Hill-System): C₁₈H₁₉N₃O₄
• CAS-Nummer: 130477-52-0
• Molekulargewicht: 341.36
• NACRES: NA.77
• PubChem Substance ID: 24278527
• UNSPSC Code: 12352200
• MDL number: MFCD02684528
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: ≥6.0 mg/mL (Warmed), H₂O: insoluble
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES string: CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12
• InChI: 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
• InChI key: YKYOQIXTECBVBB-AWEZNQCLSA-N
• Gene Information: human ... GABRA5(2558)

Beschreibung

Application

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

Biochem/physiol Actions

Ligand for benzodiazepine site of GABA_A receptors containing α₅ subunits.

Novel ligand selective for the benzodiazepine site of GABA_A receptors which contain the α₅ subunit.

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)