About 30% of the collection is made up of drugs approved for use in the US.
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LO4100
LOPAC®1280 – Kleiner Maßstab
Synonym(e):
Library of Pharmacologically Active Compounds – Kleinmaßstab
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|
Über diesen Artikel
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Form:
liquid
Quality level:
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenform
liquid
Quality Level
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
shipped in
dry ice
storage temp.
−20°C
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General description
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.[1]
Application
LOPAC® 1280 - Small Scale has been used:
- in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis[2][3]
- for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay[1]
- for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors[4]
Features and Benefits
SDFile bereitgestellt für den Aufbau einer Datenbank mit den folgenden Parametern:
- Struktur
- Primärer Name
- Sekundärer Name
- Pharmakologische Aktivität
- Produktnummer
- Gestellposition
Umfasst die aktuellsten Arzneimittel-ähnlichen Moleküle in den Bereichen von zellulärer Signaltransduktion & Neurowissenschaft:
- Apoptose
- G-Proteine & zyklische Nukleotide
- Genregulierung & -expression
- Ionenkanäle
- Lipidsignalwege
- Mehrfachresistenz gegen Arzneimittel
- Neurotransmission
- Phosphorylierung
Other Notes
For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.
Legal Information
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
188.6 °F
flash_point_c
87 °C
wgk
WGK 3
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
Martin Michael Peter Schulz et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), E2665-E2674 (2012-09-06)
Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisition and
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a
Artikel
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| LO4100-1EA | 04061833967249 |
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 US approved?
1 answer-
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?
1 answer-
Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.
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What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?
1 answer-
The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280
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Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?
1 answer-
There is no CAS number list available.
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Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?
1 answer-
The information is available in the datasheet of a similar product LO1280.
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Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?
1 answer-
Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at [email protected] or 1800-325-5832.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?
1 answer-
The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.
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What is the difference between the LOPAC1280 Products LO4100 and LO4200?
1 answer-
These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.
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