M1387

4-Methylpyrazol -hydrochlorid

alcohol dehydrogenase inhibitor

• Synonym(e): Fomepizole
• Empirische Formel (Hill-System): C₄H₆N₂ · HCl
• CAS-Nummer: 56010-88-9
• Molekulargewicht: 118.56
• NACRES: NA.77
• PubChem Substance ID: 24278534
• MDL number: MFCD00012707
• UNSPSC Code: 12352100

Eigenschaften

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥95%
• form: powder
• mp: 157-159 °C
• solubility: methanol: 100 mg/mL, clear, colorless to yellow
• storage temp.: 2-8°C
• SMILES string: Cl.Cc1cn[nH]c1
• InChI: 1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
• InChI key: PUCXJHNDMYZOHG-UHFFFAOYSA-N
• Gene Information: human ... ADH1A(124), ADH1B(125), ADH1C(126)

Beschreibung

Application

4-Methylpyrazole hydrochloride has been used:

• as a cytochrome P450 2E1 inhibitor
• as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
• to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.

Alcohol dehydrogenase inhibitor

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves