M2949

MDL 72527

≥98% (HPLC), spermine oxidase SMO inhibitor, powder

• Synonym(e): CPC-200, MDL-72527DA, N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride, N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride
• Empirische Formel (Hill-System): C₁₂ H₂₀ N₂·2 HCl
• CAS-Nummer: 93565-01-6
• Molekulargewicht: 265.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817958
• NACRES: NA.77
• MDL number: MFCD13152261
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: MDL 72527, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to brown
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: room temp
• SMILES string: Cl.Cl.C=C=CCNCCCCNCC=C=C
• InChI: 1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H
• InChI key: ITVRWVVFVHINOH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO).

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable