This product is sold by units and the vial content will vary from lot to lot. The minimum activity is 50 units/mg. The least amount that will be present in vial is 0.1 mg (100 ?g). The lot-specific activity is reported on the Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/m6908#product-documentation
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M6908
Myeloperoxidase aus Humanleukocyten
lyophilized powder, ≥50 units/mg protein
Synonym(e):
MPO, Peroxidase, myelo
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 units | Warenkorb auf Verfügbarkeit prüfen | € 470,00 |
Über diesen Artikel
CAS-Nummer:
NACRES:
NA.32
UNSPSC Code:
12352200
MDL number:
EG-Nummer:
eCl@ss:
32160410
Technischer Dienst
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Unterstützung erhaltenbiological source
human leucocytes
Quality Segment
form
lyophilized powder
specific activity
≥50 units/mg protein
solubility
H2O: soluble, aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
InChI key
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Gene Information
human ... MPO(4353)
General description
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Application
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Biochem/physiol Actions
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Physical form
Lyophilisiert aus 0.02 M Natriumacetat-Puffer, pH 6.0
Analysis Note
Das Ausgangsmaterial wurde getestet und reagierte negativ auf Antikörper gegen HIV und HBSAG.
Other Notes
1 U produziert einen Anstieg der Absorption (A470) von 1.0 pro Minute bei pH 7.0 und 25 °C, errechnet aus der Anfangsreaktionsgeschwindigkeit unter Verwendung von Guaiacol als Substrat. Gesamtreaktionsvolumen: 3.035 mL.
Lysosomales Protein, das Häm enthält.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description lyophilized powder, ≥50 units/mg protein | description lyophilized powder (essentially salt-free), ≥200 units/mg protein | description A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of proteins. | description Type II, essentially salt-free, lyophilized powder, 150-250 units/mg solid (using pyrogallol) |
| biological source human leucocytes | biological source bovine milk | biological source human | biological source horseradish |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form lyophilized powder | form lyophilized powder (essentially salt-free) | form lyophilized | form essentially salt-free, lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| shipped in dry ice | shipped in - | shipped in wet ice | shipped in - |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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how much MPO in mg or ug are on 5 units of Mpo
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