N0915

NSC43067

≥98% (HPLC)

• Synonym(e): 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067
• Empirische Formel (Hill-System): C₁₄H₁₂OS
• CAS-Nummer: 26903-26-4
• Molekulargewicht: 228.31
• NACRES: NA.77
• PubChem Substance ID: 329818472
• UNSPSC Code: 12352202
• MDL number: MFCD00489751
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to light tan
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(s1)C(=O)\C=C\c2ccccc2
• InChI: 1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+
• InChI key: AOUMOFQEBZGSPD-CMDGGOBGSA-N

Beschreibung

Biochem/physiol Actions

Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket.

NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Sicherheitshinweise: P264 - P270 - P273 - P301 + P312 - P501
• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H413
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable