P0878

O-Phospho-L-Serin

≥98% (TLC), powder, glutamate synthase (ferredoxin)] inhibitor

• Synonym(e): L-2-Amino-3-hydroxypropionsäure-3-phosphat, L-Serin-O-phosphat
• Lineare Formel: (HO)₂P(O)OCH₂CH(NH₂)CO₂H
• CAS-Nummer: 407-41-0
• Molekulargewicht: 185.07
• NACRES: NA.32
• PubChem Substance ID: 24277998
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• EC Number: 206-986-0
• MDL number: MFCD00065935
• Beilstein/REAXYS Number: 1726826
• Form: powder
• Storage condition: under inert gas

Eigenschaften

• Produktname: O-Phospho-L-Serin,
• form: powder
• Quality Segment: 200
• storage condition: under inert gas
• mp: 190 °C (lit.)
• SMILES string: N[C@@H](COP(O)(O)=O)C(O)=O
• InChI: 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
• InChI key: BZQFBWGGLXLEPQ-REOHCLBHSA-N
• Gene Information: human ... GRM4(2914), GRM7(2917), GRM8(2918)

Beschreibung

Application

O-Phospho-L-serine has been used:

• for the expression, purification and phosphorylation of protein
• to study its chemical shift
• to spectroscopically determine its pKa values using Raman spectroscopy

Biochem/physiol Actions

O-Phospho-L-serine (L-SOP) is a molecule which resembles phosphatidylserine head group and it mediates partial inhibition of microglial phagocytosis of apoptotic cells. In zebrafish, L-SOP inhibits Müller glia proliferation and blocks cone cell regeneration in the light-damaged retina. In vivo, L-SOP acts as a substrate for CysM, a cysteine synthase from Mycobacterium tuberculosis.

Group III metabotropic glutamate receptor agonist (mGluR₄, mGluR₇, and mGluR₈).

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• Gefahrencodes: H314
• Sicherheitshinweise: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Skin Corr. 1B
• Lagerklasse: 8A - Combustible corrosive hazardous materials
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)