P7903

Pipemidinsäure

• Synonym(e): 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido[2,3-d]pyrimidin-6-carbonsäure
• Empirische Formel (Hill-System): C₁₄H₁₇N₅O₃
• CAS-Nummer: 51940-44-4
• Molekulargewicht: 303.32
• NACRES: NA.85
• PubChem Substance ID: 24898889
• UNSPSC Code: 51282938
• EC Number: 257-530-2
• MDL number: MFCD00057291

Eigenschaften

• form: powder
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes, cell wall synthesis | interferes, enzyme | inhibits
• SMILES string: CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3
• InChI: 1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
• InChI key: JOHZPMXAZQZXHR-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Beschreibung

General description

Chemical structure: quinolone

Application

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Biochem/physiol Actions

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Analysis Note

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Other Notes

10g,100g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H317,H334
• Sicherheitshinweise: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Faceshields, Gloves