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P8014

4α-Phorbol 12,13-Didecanoat

Name: 4&#945;-Phorbol 12,13-Didecanoat
Brand: SIGMA
Price: 204 EUR

transient receptor potential vanilloid 4 agonist, solid

Synonym(e):

4α-PDD, 4α-Phorbol-12,13-dicaprinat

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Größe/SKU	Verfügbarkeit	Preis
1 mg	Warenkorb auf Verfügbarkeit prüfen	€ 204,00

Über diesen Artikel

Empirische Formel (Hill-System):

C₄₀H₆₄O₈

CAS-Nummer:

27536-56-7

Molekulargewicht:

672.93

NACRES:

NA.77

PubChem Substance ID:

24898900

UNSPSC Code:

12352211

MDL number:

MFCD00036737

Beilstein/REAXYS Number:

2514324

Form:

solid

€ 204,00

Warenkorb auf Verfügbarkeit prüfen

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Eigenschaften

Produktname

4α-Phorbol 12,13-Didecanoat, solid

form

solid

Quality Segment

100

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key

DGOSGFYDFDYMCW-OEFRVDPMSA-N

Beschreibung

Application

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

to study its effects on Madin-Darby canine kidney (MDCK) cells
to study its effects on Ca²⁺ influx in mice fallopian tubal cells
to study its effects on hind paw swelling in mice

Biochem/physiol Actions

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

Preparation Note

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Disclaimer

Photosensitive

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Dieser Artikel	524394	P148	P1269
Sigma-Aldrich P8014 4α-Phorbol 12,13-Didecanoat	Sigma-Aldrich 524394 4α-Phorbol-12,13-didecanoat	Sigma-Aldrich P148 4α-Phorbol 12-myristate 13-acetate	Sigma-Aldrich P1269 Phorbol-12,13-dibutyrat
description solid	description Inactive on mouse skin as an inflammatory and tumor-promoting agent.	description solid, ≥95% (TLC)	description ≥98% (TLC), powder
form solid	form solid	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility ethanol: soluble, DMSO: soluble, methanol: soluble	solubility ethanol: soluble, DMSO: soluble	solubility ethanol: soluble, H₂O: ~2 μM, DMSO: soluble	solubility DMSO: soluble, H₂O: 30 μM, acetone: soluble, ethanol: soluble
color white	color -	color white	color clear light yellow