S5576

SKA-31

≥98% (HPLC)

• Synonym(e): Naphtho[1,2-d]thiazol-2-ylamine
• Empirische Formel (Hill-System): C₁₁H₈N₂S
• CAS-Nummer: 40172-65-4
• Molekulargewicht: 200.26
• NACRES: NA.25
• PubChem Substance ID: 329824457
• UNSPSC Code: 12352202
• MDL number: MFCD00051329
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥30 mg/mL
• storage temp.: −20°C
• SMILES string: Nc1nc2c(ccc3ccccc23)s1
• InChI: 1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
• InChI key: FECQXVPRUCCUIL-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀ is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.

SKA31 is an activator of KCa2 and KCa3.1

SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H319
• Sicherheitshinweise: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable